SpOT Infrastructure

The Spatial Omics & Technologies (SpoT) infrastructure performs spatial transcriptomic and proteomic analyses in the Pays de la Loire region.

These advanced technologies analyse the transcriptome or proteome of cells while preserving their physical location and interactions within the tissue.Spatial biology thus makes it possible to determine cellular heterogeneity in complex samples and decode intercellular communications by analysing the transcriptome or proteome associated with their physical proximity within the tissue.

Due to its potential for numerous areas of biological and health research, spatial transcriptomic analysis was declared the method of the year 2020 by the journal Nature Methods.'¹

¹ Marx V. Method of the Year: spatially resolved transcriptomics. Nat Methods Volume 18 Issue 1. 2021.

- available for service in 2026 -

SpOT will offer comprehensive solutions for high-resolution biological tissue analysis:

• Spatial transcriptomic analyses of the entire transcriptome and more targeted subcellular analyses.
• Spatial proteomic analyses.
• Creation of TMA (Tissue MicroArrays)
• Expertise in the optimal handling of all types of samples
• Synergy with other platforms

Skills and Equipments

The SpoT infrastructure complements and supports existing structures recognised for their technical and scientific expertise.

 Managed by SpOT and located at
 Plateforme du Service Commun de Microscopie électronique, Microcaractérisation et Morpho-histologie-imagerie fonctionnelle

 Managed by SpOT and located at

 Plateforme d'histologie, d'imagerie cellulaire et tissulaire et d'analyses d'images

 to optimise spatial analyses

Managed by SpOT and located at

   Plateforme d'histologie, d'imagerie cellulaire et tissulaire et d'analyses d'images
 

 Managed by SpOT and located at

Plateforme interne de génomique du CR2TI

 Complementary to spatial analyses

Plateforme interne de génomique du CR2TI

And Plateforme de génomique

necessary for managing the data generated within the infrastructure. 

plateforme de bioinformatique
And   Groupement Ligérien pour le Calcul Intensif Distribué

Complementarity

The SpOT infrastructure is made possible thanks to the support of 9 laboratories in the Loire region, most of which are grouped together within the SFR Bonamy of Nantes :

Regenerative Medicine and Skeleton, RMeS Inserm UMR1229 / Nantes Université


Center for Research in Transplantation and Translational Immunology, CR2TI Inserm UMR1064 / Nantes Université


L’institut du thorax, Inserm UMR1087 / CNRS UMR6291 / Nantes Université



Centre de Recherche en Cancérologie et Immunologie Nantes-Angers, CRCI2NA Inserm UMR1307 / CNRS UMR6075 / Nantes Université,

including the partnership with l’institut de Cancérologie de l’Ouest (ICO)
 

Translational Research in Gene Therapy, TaRGeT Inserm UMR1089 / Nantes Université


The Enteric Nervous System in Gut and Brain Disorders, TENS Inserm UMR1235 / Nantes Université

 

Physiologie des Adaptations Nutritionnelles, PhAN INRAe UMR1280 / Nantes Université
 

Immunologie et Nouveaux Concepts en Immunothérapie, INCIT Inserm UMR1302 / CNRS EMR 6001 / Nantes Université
 

PAnTher 

Physiopathologie Animale et bioThérapie du muscle et du système nerveux, PAnTher INRAe UMR703

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The SpOT infrastructure, within the BioCore UMS, is funded by the Pays de la Loire Region as part of the 2024 call for projects for ‘Loire Valley research infrastructures’.