Organoids Infrastructure Nantes

A unique offering of integrated services covering all areas of expertise in organoids from the laboratories and platforms at the Nantes site.

Expertise

The ION research infrastructure provides organoid models to the scientific community and healthcare companies. To do this, ION brings together expertise from laboratories in Nantes, focusing on the use and study of several types of organoids (e.g. organ avatars) representing all the organs and diseases studied, as shown in the diagram below.

infrastructure-organoides@univ-nantes.fr

Maxime Mahé, scientific manager – chercheur UMR1235 TENS
Laurent David, deputy scientific manager – iPSC core facility scientific manager

ORGANOIDS PRODUCTION

Scientific in the Nantes region have pooled their expertise to offer you a comprehensive multi-organ study service.

Organs for which at least one team in Nantes has developed an organoid, spheroid or tumoroid

ORGANOIDS ANALYSIS

The teams at the Nantes core facilities are also able to characterise the generated 3D structures.
 

                                                   Imaging                           Transcriptomic                                  Cytometry                     Biomechanics                 Cellular models
                              
                                    MicroPICell  Core Facility                GenoA Core Facility                 Cytocell Core Facility       Bio3  Core Facility         Therassay Core Facility

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         HIO/Intestin ©Maxime Mahé                     Blastocyste ©Laurent David   MCTS/mésothélium ©Christophe Blanquart     Rhéomètre ©PF Bio3

Organoids are cellular models that are an intermediate step between monolayer cell cultures and in vivo models. They have been developed thanks to advances in stem cell culture and differentiation, as well as 3D culture, over the last few decades. These three-dimensional models have the advantage of being produced from cells of the same species, unlike animal models. Using them therefore makes it possible to replicate physiological and/or pathophysiological conditions more closely, thereby increasing our knowledge of tissue function in the presence or absence of external molecules.

These rapidly developing technologies meet the requirement to reduce the use of animal models in accordance with the 3Rs principle (FC3R)

• All scientists in the Loire and Western France regions who are developing or studying organoids are listed on a map available on thePage OuestOïd (projet fédérateur Biogenouest)
• Learn more about organoids - Demystification: understanding organoids and their applications
• The TENS laboratory has popularised its work on intestinal organoids in the form of an O'tablo

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Funders